EFFECT OF CIANIDANOL (KB-53) ON THE ACTIVITY OF MOUSE CYTOTOXIC-T-LYMPHOCYTES
スポンサーリンク
概要
- 論文の詳細を見る
The effect of cianidanol (KB-53) on the mouse cytotoxic-T-lymphocyte (CTL) activity of the splenic cells was investigated. The CTI, activity of the splenic cells prepared from C3H/He, DBA/2 and CBA strain mice which had been sensitized with EL-4 cells were recognized markedly 11 d after the sensitization. The CTL activity showed an antigen specificity. KB-53,in a dose range of 125-1000 mg/kg, augmented the mouse CTL activity in a dose-dependent manner by oral administration once daily for 5 d beginning immediately after the sensitization. This CTL activity disappeared with treatment of the splenic cell with anti-thy-l serum and normal guinea pig scrum, therefore, it was confirmed that the cytotoxic activity of the splenic cells which were prepared from the mice sensitized with EL-4 cells depended on the T-cell activity.
- 公益社団法人日本薬学会の論文
著者
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石黒 京子
武庫川女大薬
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石黒 京子
武庫川女子大学生薬学研究室
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ITO KEIZO
Pharmaceuticals Research Center, Kanebo Ltd.
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Ishiguro Kyoko
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ.
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石黒 京子
Mukogawa Women's Univ. Nishinomiya Jpn
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石黒 京子
武庫川女子大学 薬
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Ishiguro Kyoko
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Sato Iwao
Pharmaceuticals Research Center Kanebo Ltd.
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Ito K
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Ito Keizo
Pharmaceuticals Research Center Kanebo Ltd.
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Tajima Shigeru
Pharmaceuticals Research Center Kanebo Ltd.
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Ikeda Y
Kanebo Institute For Cancer Research Kanebo Co. Ltd.
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NOSE Takashi
Pharmaceuticals Research Center, Kanebo, Ltd.
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IKEDA YOSHIAKI
Pharmaceuticals Research Center, Kanebo Ltd.
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KAWAKAMI KIYOTAKA
Pharmaceuticals Research Center, Kanebo Ltd.
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Nose T
Functional Devices Research Laboratories Nec Corporation
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Kawakami Kiyotaka
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Nose Takashi
Pharmaceuticals Research Center Kanebo Ltd.
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