SUBACUTE TOXICITY AND RECOVERY TESTS OF INTRAVENOUS DEHYDROEPIANDROSTERONE SULFATE (DHA-S) IN BEAGLE DOGS

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At dose levels of 5, 20 and 60 mg/kg, dehydroepiandrosterone sulfate (DHA-S) was given intravenously for 30 successive days to female beagle dogs with the following results. 1) The chief general symptoms were vomiting, salivation and discharge of milk. Vomiting and salivation developed after the drug in doses of more than 20 mg/kg and in the dose of 60 mg/kg respectively, while discharge of milk was seen in dogs treated with the drug of more than 20mg/kg. 2) Hematological, serum biochemical and urinary examinations revealed no abnormalities. 3) Examination of organ weights disclosed only an increasing tendency of the liver weight in 60mg/kg group. 4) Histological findings were slight degranulation of the pituitary basophil in 60mg/kg group and atrophic tendency of the thymus in 1 out of the 3 dogs of the same group. Narrowing of the adrenal zona fasciculata occurred in 1 out of the 3 dogs of 60mg/kg group. Luteinization in the ovary was especially remarkable in 60mg/kg group. Secretion from the uterine glandular cell and edematous tendency of the endometrium were detected mostly in 60mg/kg group. Dogs of 20 and 60mg/kg groups showed proliferation of mammary gland cells with discharge of milk. 5) There were no abnormalities on electron micrography of the liver. 6) All changes mentioned above essentially disappeared during the recovery test of 1 month's duration. Therefore, a possible maximum dose of DHA-S which does notcause adverse reaction was evidenced to be about 20 mg/kg in dogs.
日本トキシコロジー学会の論文
1977-04-15

SUBACUTE TOXICITY AND RECOVERY TESTS OF INTRAVENOUS DEHYDROEPIANDROSTERONE SULFATE (DHA-S) IN BEAGLE DOGS

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