Preventive Effects of Impatiens balsamina on the Hen Egg-White Lysozyme (HEL)-Induced Decrease in Blood Flow
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概要
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Monitoring the blood flow of unanesthesized mice was found to be a reliable and effective method for studying their anaphylactic responses, in addition to the known method of monitoring blood pressure. Hen egg-white lysozyme (HEL)-specific anaphylaxis in mice was estimated by monitoring the decrease in blood flow with a Doppler blood flow meter. This method is convenient for searching for both anaphylaxis and anti-anaphylactic substances from natural products. Using this system, we estimated the anti-anaphylactic effects of the 35% ethanol extract (IB) of petals of Impatiens balsamina L., as well as those of anti-allergic agents currently used. Kaempferol 3-rutinoside and lawsone from IB significantly inhibited the decrease of blood flow. We also found that platelet-activating factor (PAF) and serotonin participate in decreasing the blood flow, but histamine does not.
- 公益社団法人日本薬学会の論文
- 2002-04-01
著者
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OKU Hisae
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
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Oku Hisae
School Of Pharmaceutical Sciences Mukogawa Women's University
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Oku Hisae
School Of Pharmaceutical Sciences Mukogawa Women 's University
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ISHIGURO Kyoko
School of Pharmaceutical Sciences, Mukogawa Women's University
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Ishiguro Kyoko
School Of Pharmaceutical Sciences Mukogawa Women 's University
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OHIRA Yukiko
School of Pharmaceutical Sciences, Mukogawa Women's University
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Ohira Yukiko
School of Pharmaceutical Sciences, Mukogawa Women's University
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