In Vitro Percutaneous Transport of Sodium Diclofenac and Diclofenac from Oleaginous Vehicle
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概要
- 論文の詳細を見る
The penetration enhancement of sodium diclofenac and diclofenac by alcohols with various alkyl chains (C_8 to C_<14>) was evaluated by the steady state flux of diclofenac through rat abdominal skin. Decanol showed the greatest effect in this series. A more remarkable enhancing effect of the alcohols was observed in sodium diclofenac than in diclofenac. Diclofenac can penetrate through the ethylene-vinyl acetate membrane as a lipoid model membrane, but sodium diclofenac can not. Decanol enhanced the penetration of phenol red being dependent on its concentration in the vehicle. Therefore, decanol may interact with lipoid components of the skin and increase the aqueous pathway in the skin. These results indicate that sodium diclofenac and diclofenac may be penetrated through partially different pathways.
- 社団法人日本薬学会の論文
- 1991-02-25
著者
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高橋 幸一
武庫川女子大学薬学部
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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水野 亘恭
Faculty of Pharmaceutical Sciences, Osaka University
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西畑 利明
カンサス大学
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吉富 博則
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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西畑 利明
Pharmaceutical Chemistry Department, The University of Kansas
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吉富 博則
福山大学
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水野 亘恭
武庫川女子大学薬学部
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高橋 幸一
Faculty of Pharmaceutical Sciences, Mukogawa University
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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玉川 智子
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Rytting J.
カンサス大学
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加多木 豊史
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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RYTTING J.Howard
Pharmaceutical Chemistry Department, University of Kansas
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鎌田 皎
大阪大学
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高橋 幸一
武庫川女子・薬
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高橋 幸一
武庫川女子大学薬学部薬剤学研究室
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加多木 豊之
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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加多木 豊史
Faculty Of Pharmaceutical Science Mukogawa University
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高橋 幸一
Faculty Of Pharmaceutical Sciences Mukogawa University
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水野 亘恭
武庫川女子大・薬
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水野 亘恭
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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玉川 智子
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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西畑 利明
Pharmaceutical Chemistry Department The University Of Kansas
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