The Absorption of Organomercurial Compounds from the Vaginal Route of the Rabbits. I. Comparative Study on the Effect of Suppository Vehicles on the Absorption of ω-Ethylmercurithio-n-undecanoic Acid, Phenylmercuric Acetate and Ethylmercuric Chloride afte

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Absorption rates of three kinds of organomercurial compounds from the rabbit's vagina were studied in refference to suppository vehicles. Several types of emulsion base and Carbowax 2000 were employed as vehicles. The compounds were labelled with isotope Hg^<203> and the blood concentration was chronologically determined after a single vaginal administration of suppository. Modifications of the composition of emulsion vehicle resulted in some changes of an actual absorption rate for phenylmercuric acetate, because of the replacement reaction of the mercurial in the vehicle. No significant differences were observed of the influences of the type and phase ratio of emulsion vehicle on the absorption rate. When Carbowax 2000 was used as vehicle, phenylmercuric acetate showed a higher blood level than that of ω-ethylmercurithio-n-undecanoic acid or ethylmercuric chloride. It was concluded that the rate of absorption of mercurial compounds contained in suppository vehicle through rabbit's vagina was related to the water solubility and oil-water distribution coefficient of the compounds employed.
社団法人日本薬学会の論文
1964-05-25