Effect of Isoxazolyl-penicillin on the Rectal Absorption of Ampicillin in Rabbits and Humans
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概要
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The effects of isoxazolyl-penicillins on the rectal absorption of ampicillin were investigated in rabbits and humans. The bioavailability of ampicillin following administration of a suppository in the presence or absence of an isoxazolyl-penicillin was determined from the blood level in rabbits and from the urinary excretion (0-6 h) in humans. Rectal absorption of ampicillin from the suppository was enhanced by the presence of an isoxazolyl-penicillin in both rabbits and humans, though the effect was much greater in rabbits than in humans. The absorption-promoting effects of isoxazolyl-penicillins appeared to be related to their partition coefficients between n-octanol and buffer solution (pH 7.4).
- 社団法人日本薬学会の論文
- 1983-05-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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村上 照夫
広島大学医学部総合薬学科医療薬剤学講座
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矢田 登
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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