Ion-Pair High-Performance Liquid Chromatographic Analysis of Sulpyrine and Its Metabolites in Rabbit Plasma
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概要
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A simple, specific and sensitive ion-pair high-performance liquid chromatographic analysis was developed for aminopyrine, sulpyrine and their metabolites (4-methylaminoantipyrine, 4-aminoantipyrine, 4-acetylaminoantipyrine and 4-formylaminoantipyrine) in rabbit plasma. Following deproteinization with acetonitrile and separation on an octadecylsilane-bonded silica column (250×4mm, JASCO Fine SIL C-18), the eluted components were detected with a multiwavelength ultraviolet monitor at 260nm. The mobile phase consisted of 22% (v/v) acetonitrile and 78% (v/v) of an aqueous solution containing 10mM KH_2PO_4 and 1.24mM tetra-n-butylammonium bromide, adjusted to pH 4.5 with 0.1M phosphoric acid solution. Hexobarbital was employed as an internal standard. Based on 0.1ml of plasma, the detection limits were 0.35μM for 4-acetylaminoantipyrine, 0.35μM for 4-formylaminoantipyrine, 0.7μM for sulpyrine, 1μM for 4-aminoantipyrine, and 2μM for 4-methylaminoantipyrine at the signal-to-noise ratio of 5 : 1.
- 公益社団法人日本薬学会の論文
- 1984-08-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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山崎 勝
Faculty of Pharmaceutical Sciences, Osaka University
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山崎 勝
大阪大学薬学部
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鈴鹿 卓美
Faculty of Pharmaceutical Sciences, Osaka University
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伊藤 壮一
Faculty of Pharmaceutical Sciences, Osaka University
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鈴鹿 卓美
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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久保 一義
Faculty of Pharmaceutical Science, Osaka University
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田部 和久
関西労災病院
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田部 和久
Hospital Attached to the Research Institute for Microbial Diseases
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古市 由美
Faculty of Pharmaceutical Sciences, Osaka University
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伊藤 壮一
大阪大学薬学部
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田部 和久
Faculty Of Pharmaceutical Sciences Osaka University
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久保 一義
Faculty Of Pharmaceutical Sciences Osaka University
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久保 一義
Faculty And Graduate School Of Pharmaceutical Sciences Osaka University
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古市 由美
Faculty Of Pharmaceutical Sciences Osaka University
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