On the Mechanism of Increased Renal Tubular Reabsorption of Drugs in Alloxan Diabetic Rabbits
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概要
- 論文の詳細を見る
A study was made on the mechanisms of increased renal tubular reabsorption of chlorpropamide, sulfadimethoxine and N^4-acethylsulfadimethoxine in diabetic rabbits. Urinary acidification with NH_4Cl increased the renal tubular reabsorption of the drugs. Reabsorption coefficients of undissociated and dissociated molecules of the drugs were calculated using data of renal clearance of the drugs in alloxan diabetic rabbits and in NH_4Cl-treated rabbits. Excellent accordance of the reabsorption coefficients as well as apparent reabsorption ratios in diabetic rabbits with those in NH_4Cl-treated rabbits was observed. It was concluded that renal tubular reabsorption of drugs depended exclusively on the urinary pH in the renal tubules. Parameters of renal tubular reabsorption in vivo could be well expressed by the parameters of distribution between CHCl_3-CCl_4 (1 : 1 by volume) containing soy bean lecithin and buffer solution.
- 公益社団法人日本薬学会の論文
- 1978-11-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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矢田 登
Faculty of Pharmaceutical Sciences, Osaka University
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西畑 利明
大阪大学薬学部
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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西畑 利明
Faculty of Pharmaceutical Sciences, Osaka University
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矢田 登
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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