Intestinal Absorption of N, N'-Dimethylcarbamoylmethyl 4-(4-Guanidinobenzoyloxy) Phenylacetate Methanesulfonate in Rats
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概要
- 論文の詳細を見る
The intestinal absorption of N, N'-dimethylcarbamoylmethyl 4-(4-guanidnobenzoyloxy) phenylacetate methanesulfonate (FOY305^[○!R]) in rats was investigated using a rat intestinal loop method. Plasma drug concentrations and the disappearance of the drug from the intestinal lumen were measured. The absorption of FOY305 after administration into a rectal loop was greater than those after administration into variously positioned small intestinal loops. The low absorption of FOY305 after administration into the small intstine was due to the rapid degradation of FOY305 by esterase activity in the small intestinal lumen.
- 公益社団法人日本薬学会の論文
- 1988-07-25
著者
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西畑 利明
大阪大学薬学部
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斉藤 由紀子
Osaka University Of Pharmaceutical Sciences
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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西畑 利明
Faculty of Pharmaceutical Sciences, Osaka University
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酒井 清
Osaka University Of Pharmaceutical Sciences
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