糖尿病態時の胃液分泌動態におよぼす抗コリン薬の挙動

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By use of the same kind of rabbits, the difference in the effects of anticholinergic drugs on the secretion of gastric juice under normal conditions from that under alloxan diabetes conditions was investigated. The pepsin activity was determined according to the method for the determination of pepsin activity established in the Committee on the examination of a method of measurement of gastric juice belonging to Japan Gastroenterological Society, the acidity by Topher-Michaelis method and the blood suger level by Glucose B-Test. The basic values such as the amount of secreted gastric juice, pepsin activity, the amount of secreted pepsin, the acidity of free hydrochloric acid, the amount of secreted free hydrochloric acid, total acidity and the amount of secreted acid under disease conditions were lower than those under normal conditions and the main causes of decreases in the amounts of secreted pepsin and acid seemed to be due to a decrease in that of secreted gastric juice. The comparison of the degrees of decrease of various kinds of amounts secreted by use of anticholinergic drugs and of each value estimated at the time with the maximum mean rate of decrease by the administration of anticholinergic drugs under both conditions afforded no significant difference. However, the amounts of various kinds of secretion reached a minimum under disease conditions earlier than those under normal conditions. Under both conditions, the time necessary for the reaction with tertiary amines was shorter than that with quaternary ammonium salts.
公益社団法人日本薬学会の論文
1983-03-25

糖尿病態時の胃液分泌動態におよぼす抗コリン薬の挙動

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