経口糖尿病薬の胃液分泌動態におよぼす抗コリン薬の影響

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By use of rabbits with alloxan diabetes the effect of anticholinergic drugs on the secretion of gastric juice after the administration of oral antidiabetics as a treatment of alloxan diabetes was examined from the standpoint of mutual interaction among drugs. The pepsin activity was determined according to the method for the determination of pepsin activity established in the Committee on the examination of a method of measurement of gastric juice belonging to Japan Gastroenterological Society, the acidity by Topher-Michaelis method and the blood sugar level by Glucose B-Test. The promoting action of the secretion of gastric juice by oral antidiabetics was inhibited by use of anticholinergic drugs. The amounts of secreted pepsin and acid showing the same tendency as that of secreted gastric juice were mainly influenced by that of secreted gastric juice. The effect was smaller in the case of the administration of anticholinergic drug 2-3h after oral antidiabetics than that in the case of the simultaneous administration of these drugs. Biguanide drugs showed higher rate of decrease from the maximum value of the amounts of secreted pepsin and acid than sulfonamide or sulfonylurea drugs. Moreover, in the case of the administration of anticholinergic drugs at a suitable interval after oral antidiabetics, the period for both secreted amounts to attain a minimun became longer after a combined treatment. The rate of decrease with quaternary ammonium salts was slightly higher than that with tertiary amines.
公益社団法人日本薬学会の論文
1983-03-25

経口糖尿病薬の胃液分泌動態におよぼす抗コリン薬の影響

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