Role of Acetone Bodies in the Abnormal Pharmacokinetic Behavior of Chlorpropamide in Alloxan Diabetic Rabbits
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概要
- 論文の詳細を見る
The effect of acetoacetic acid (AA) or β-hydroxybutyric acid (HBA), each of which is a component of acetone bodies, on the pharmacokinetic behavior of chlorpropamide (CPA) was studied in order to elucidate the reason for the abnormal behavior of CPA under diabetic conditions. The serum level of CPA in the elimination phase showed a rapid and profound fall immediately after intravenous administration of AA. A change of distribution of CPA in the blood was observed in a normal rabbit. However, under diabetic conditions, with high blood levels of acetone bodies, the effect of AA was temporary. A marked decrease of proximal tubular secretion of CPA was observed under normal conditions after the administration of AA. HBA showed effects similar to those of AA. A marked increase of CPA in red blood cells was observed in the presence of AA or HBA in normal rabbits. These results coincide with those obtained under diabetic conditions. It was concluded that the retardation of urinary excretion and the increase in the distribution of CPA into red blood cells in alloxan diabetic rabbits is mainly due to the presence of acetone bodies in the blood.
- 公益社団法人日本薬学会の論文
- 1979-08-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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矢田 登
Faculty of Pharmaceutical Sciences, Osaka University
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西畑 利明
大阪大学薬学部
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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西畑 利明
Faculty of Pharmaceutical Sciences, Osaka University
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矢田 登
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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