Effect of Salicylate on the Binding of Sulfonamides to Bovine Serum Albumin
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概要
- 論文の詳細を見る
Displacement of eight sulfonamides by sodium salicylate from the binding sites of bovine serum albumin (BSA) was studied by the equilibrium dialysis method at pH 7.4 and 37°. Amount of sulfonamides displaced by the addition of salicylate (1 or 3 mM) were linearly correlated with their amount bound to the binding sites of BSA in the absence of salicylate. Double-reciprocal plots of the binding of sulfamethoxazole to BSA with and without salicylate, following Langmuir's isotherms, resulted in linear curves with a common ordinate intercept. This result suggests that the inhibitory effects of salicylate on the binding of sulfamethoxazole to albumin were competitively performed at the same binding site on the protein.
- 公益社団法人日本薬学会の論文
- 1978-11-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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西畑 利明
大阪大学薬学部
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東 豊
広島大・医・総合薬
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東 豊
広島大学・医・総合薬学科
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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矢田 登
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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久保 一義
Faculty Of Pharmaceutical Sciences Osaka University
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東 豊
Faculty of Pharmaceutical Sciences, Osaka University
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