ピリドキシン脂肪酸エステルの薬剤学的研究 : (VII)PyridoxineおよびPyridoxine 3,4-dioctanoateの経皮吸収(2)経皮吸収におよぼす基剤の影響

概要

論文の詳細を見る
The effect of vehicles on percutaneous and intradermal absorptions of pyridoxine (PIN) and pyridoxine 3,4-dioctanoate (PIN-DK) was studied in rabbit. PIN was easily absorbed from an oleyl alcohol vehicle but not from hydrophilic vehicles. Irrespective of hydrophilic or lipophilic vehicles, PIN was easily absorbed from all vehicles planted into derm of the rabbit abdomen. The blood concentration reached maximum within one hour after the plantation. It was concluded that the barrier in rabbit skin was important for the percutaneous absorption of PIN. A study of percutaneous and intradermal absorptions of PIN-DK revealed that the blood concentration increased slowly and was influenced slightly by the change of vehicles. For the percutaneous absorption of PIN-DK, the presence of barrier had little influence. PIN-DK was found to penetrate little through the skin with an in vitro experiment, but PIN, a product of PIN-DK after an enzymatic hydrolysis, did. It was considered that PIN-DK could permeate into the barrier because of its lipophilic property but could not penetrate into blood because of its poor water solubility. The rate limiting process for the percutaneous absorption of PIN-DK was concluded to be an enzymatic hydrolysis during the penetration through the skin.
日本ビタミン学会の論文
1969-01-25