α^4-N-Acyl pyridoxamineの合成及びα^4-N-Octanoyl pyridoxamineの加水分解

概要

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3,α^4-Di-O-dioctanoyl pyridoxine was transformed into α^4-N-octanoyl pyridoxamine by reacting with ammonia at 60℃ for 3 hours. This conversion also occurred with α^4,α^5-Di-O-dioctanoyl pyridoxine and 5-O-octanoyl pyridoxine at the same condition. α^4-N-Octanoyl pyridoxamine was also synthesized by reaction of pyridoxamine HCl with caprylyl chloride. α^4-N-octanoyl pyridoxamine obtained by the two methods agreed in mp, IR and thin layer chromatography. α^4-N-acetyl pyridoxamine and α^4-N-lauroyl pyridoxamime were synthesized in the same manner. Solubilities of α^4-O-octanoyl pyridoxine and α^4-N-octanoyl pyridoxamine in organic solvents and their spectronic properties were measured. Effect of boric acid on the colouration of pyridoxamine derivatives with a 2,6 -dibro-moquinonechloroimide was studied. Hydrolysis of α^4-N-octanoyl pyridoxa mine by acid, alkali and enzymes was also investigated.
日本ビタミン学会の論文
1976-03-25