Rectal Absorption of Lysozyme and Heparin in Rabbits in the Presence of Non-surfactant Adjuvants
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概要
- 論文の詳細を見る
Ethylacetoacetate enamines of phenylalanine and phenylglycine enhanced the rectal absorption of macromolecular drugs such as lysozyme and heparin in rabbits. Glycerine-1,3-diacetoacetate, 1,2-isopropylideneglyceryl-3-acetoacetate and ethylacetoacetylglycolate also enhanced the rectal absorption of lysozyme and heparin. Lysozyme is a basic compound and heparin is an acidic compound, so the non-surfactant adjuvants used in this study can promote the rectal absorption of macromolecular compounds irrespective of their electrochemical properties. The coadministration of calcium ion inhibited the adjuvant action, so complex formation of the adjuvant with calcium ion may occur, reducing the efficacy of these compounds as adjuvants.
- 公益社団法人日本薬学会の論文
- 1984-05-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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西畑 利明
大阪大学薬学部
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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西畑 利明
Faculty of Pharmaceutical Sciences, Osaka University
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鎌田 皎
大阪大学
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三宅 正敏
Technological Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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三宅 正敏
Faculty of Pharmaceutical Sciences, Osaka University
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和田 穂子
Faculty of Pharmaceutical Sciences, Osaka University
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竹島 恵美子
Faculty of Pharmaceutical Sciences, Osaka University
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三宅 正敏
Technological Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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竹島 恵美子
Faculty Of Pharmaceutical Sciences Osaka University
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Miyake M
Technological Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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和田 穂子
Faculty Of Pharmaceutical Sciences Osaka University
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