Enamine Formation of Various Amino Acids with Ethyl Acetoacetate in Aqueous Solution in Relation to Colonic Absorption of Cefmetazole
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概要
- 論文の詳細を見る
Amino acids such as DL-Ala, Gly and L-Leu form the enamine with ethyl acetoacetate even in aqueous solution, as determined by ultraviolet (UV)-spectrophotometry. Although the observed formation constant, K_<obs>, of the enamine from each amino acid showed a dependency on pH, the values of the intrinsic enamine formation constant, K, were rather similar for all the amino acids and showed no dependence on pH. A solution containing a mixture of ethyl acetoacetate and an amino acid increased the colonic absorption of cefmetazole significantly. The extent of the absorption enhancement depended on the pK_a of the amino group of the amino acid contained in the test solution.
- 公益社団法人日本薬学会の論文
- 1985-07-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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西畑 利明
大阪大学薬学部
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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西畑 利明
Faculty of Pharmaceutical Sciences, Osaka University
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鎌田 皎
大阪大学
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趙 梨花
Faculty of Pharmaceutical Sciences, Osaka University
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稲垣 秀樹
Faculty of Pharmaceutical Sciences, Osaka University.
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稲垣 秀樹
Faculty Of Pharmaceutical Sciences Osaka University.
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趙 梨花
Faculty Of Pharmaceutical Sciences Osaka University
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