ピリドキシン脂肪酸エステルの薬剤学的研究 : (V)数種エステルの人における消化管吸収
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概要
- 論文の詳細を見る
Gastro-intestinal absorption of fatty acid esters of pyridoxine was studied in human by the oral administration of 243.3 μmoles. It was found that the urinary excretion of pyridoxine 5-octanoate and 3,4-dioctanoate in 48 houre was as large as pyridoxine, but those of pyridoxine 3,4-dilaurate and -dipalmitate were small. By the study of thin-layer chromatography, the main metabolite of the esters was 4-pyridoxic acid, i.e., the same metabolite of pyridoxine. From the present study, it was found that the esters were hydrolyzed to pyridoxine in the human body. There was a good correlationship between the intestinal absorption of the esters in human and their penetration through everted sac of the rat intestine. The differences of absorption and penetration between the esters were closely correlated with the differences of degree of hydrolysis by homogenates of the mouse intestine.
- 日本ビタミン学会の論文
- 1968-08-25
著者
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青木 大
Faculty Of Pharmaceutical Sciences Osaka University
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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水野 亘恭
大阪大学薬学部薬剤学教室
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青木 大
大阪大学薬学部薬剤学教室
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鎌田 皎
大阪大学薬学部薬剤学教室
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水野 亘恭
武庫川女子大学薬学部
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水野 亘恭
武庫川女子大・薬
関連論文
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