ジブカイン塩基の物理化学的性質および作用性に及ぼす対イオンの影響に関する研究(第1報) : 親媒性と表面麻痺作用に及ぼす影響
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概要
- 論文の詳細を見る
Ten kinds of dibucaine salts were prepared. Effects of some counter ions on effective duration of surface anesthesia with dibucaine base on the rabbit cornea were studied, with reference to their effects on physicochemical properties of the base. Solvent affinity of dibucaine base, especially solubility in water and distribution ratio between chloroform and water were found to be influenced by the presence of counter ions. It seemed that the change in solvent affinity was influenced by the change of hydrolytic constant of dibucaine salts. Logarithmic plots of effective duration against distribution ratio revealed a significant correlation coefficient of r=0.81. It was demonstrated that the higher the distribution ratio, the longer the effective duration.
- 公益社団法人日本薬学会の論文
- 1966-09-25
著者
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青木 大
Faculty Of Pharmaceutical Sciences Osaka University
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青木 大
大阪大学薬学部薬剤学教室
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矢田 登
大阪大学薬学部薬剤学教室
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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