Biopharmaceutical Studies of Thiazide Diuretics. I. Determination of pK_a Values and Partition Coefficients of Thiazide Diuretics
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概要
- 論文の詳細を見る
The overlapping pK_a values of several thiazide diuretics were determined at 25±2℃ by an improved spectrophotometric method. The absorbance of the ionized form cannot be measured directly due to the overlapping, but can be calculated from the data obtained experimentally in a region where overlapping does not occur. This method can be used to determine the pK_a values of drugs to which the usual means available for measurement of the ionization constants cannot be applied. The partition coefficients of these drugs between water and n-octanol were also determined at pH 2-10,and the behavior on an adsorption chromatographic column was studied. The pH profiles of both characteristics were very similar.
- 社団法人日本薬学会の論文
- 1984-06-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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山崎 勝
Faculty of Pharmaceutical Sciences, Osaka University
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折田 義正
Osaka University Medical School
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折田 義正
大阪大学病態生体情報学
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山崎 勝
大阪大学薬学部
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武田 美雄
Faculty of Integrated Arts and Sciences, University of Tokushima
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武田 美雄
徳島大総科
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大橋 佳代子
Faculty Of Pharmaceutical Sciences Osaka University
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鈴鹿 卓美
Faculty of Pharmaceutical Sciences, Osaka University
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伊東 容子
Faculty of Pharmaceutical Sciences, Osaka University
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伊藤 壮一
Faculty of Pharmaceutical Sciences, Osaka University
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北村 美保子
Faculty of Pharmaceutical Sciences, Osaka University
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中浜 肇
Osaka University Medical School
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中浜 肇
兵庫医科大学第五内科
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中浜 肇
大阪大学
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武田 美雄
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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鈴鹿 卓美
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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伊東 容子
Faculty Of Pharmaceutical Sciences Osaka University
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伊藤 壮一
大阪大学薬学部
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北村 美保子
Faculty Of Pharmaceutical Sciences Osaka University
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