浸透圧クリアランス, 自由水クリアランスよりみた尿濃縮機構, 特に集合管機能の評価

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To evaluate the renal countercurrent system, authors already reported the significance of the urinary concentrating ability (mOsm/kg H_2O) and the index of renal water economy. In this paper, the significance of negative free water clearance, one of the important indices which were considered to express the renal countercurrent system, was examined. Material and Method 1) The relation between osmolal clearance and negative free water clearance in the healthy human subjects : Fishberg's concentration test was performed for twenty year-old healthy girls (twenty students of the Nursing School of Osaka University) under the dietary condition of 70g protein and 10g salt. Near the third urinary voiding, blood was taken from the each person. Urinary osmolality and serum osmolality were measured by Advance osmometer. Urinary volume was also measured. Then, osmolal clearance and free water clearance were calculated by the formula generally used. 2) The relation between osmolal clearance and negative free water clearance in the patients with renal diseases. Fishberg's concentration test was performed for eighteen out-patients of the renal diseases clinic in our faculty. The procedures were same as that of the healthy person except a strict dietary condition. 3) The relation between osmolal clearance and free water clearance in the healthy human subjects and the patients with renal diseases under a condition of a gradual change of urine flow. Three healthy human subjects, three patients with chronic glomerulonephritis and three patients with chronic pyelonephritis were fasted and their urinary volume was gradually increased, then decreased by a careful control of water drinking. Each urinary volume was measured at twenty minutes period. Urinary and serum osmolality were measured by Fiske Os mometer. Then, the calculation was performed as the previous experiments.
社団法人日本循環器学会の論文
1968-07-20

浸透圧クリアランス, 自由水クリアランスよりみた尿濃縮機構, 特に集合管機能の評価

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