Determination of Ticlopidine in Rabbit Plasma by High-Performance Liquid Chromatography(Pharmaceutical)
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概要
- 論文の詳細を見る
A method for determination of ticlopidine in plasma by high-performance liquid chromatography was established. The plasma samples (0.2ml) were extracted with hexane. After evaporation, the hexane extracts were redissolved in the mobile phase containing phenobarbital as an internal standard, and an appropriate volume was injected onto a column of Cosmosil 5C8 (150×4mm, i.d.); mobile phase, acetonitrile-10mM phosphate buffer of pH 4.0 (30:70 v/v); flow rate, 1.0ml/min; spectrophotometric detection at 230 nm. Ticlopidine and the internal standard were separated from interfering plasma components by this method. The peak height ratio of ticlopidine to the internal standard was proportional to the ticlopidine concentration in the range from 0.1 to 2.0μg/ml.
- 公益社団法人日本薬学会の論文
- 1987-03-25
著者
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山崎 勝
Faculty of Pharmaceutical Sciences, Osaka University
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山崎 勝
大阪大学薬学部
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伊藤 壮一
Faculty of Pharmaceutical Sciences, Osaka University
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澤ノ井 政美
大阪大学微生物病研究所附属病院薬剤部
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田部 和久
関西労災病院
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鈴木 新治
Faculty of Pharmaceutical Sciences, Osaka University
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安藤 秀一
Faculty of Pharmaceutical Sciences, Osaka University
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船津 由美子
Faculty of Pharmaceutical Sciences, Osaka University
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田部 和久
Osaka University Hospital
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澤ノ井 政美
Hospital Attached to the Research Institute for Microbial Diseases, Osaka University
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伊藤 壮一
大阪大学薬学部
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田部 和久
Faculty Of Pharmaceutical Sciences Osaka University
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安藤 秀一
Faculty Of Pharmaceutical Sciences Osaka University
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沢ノ井 政美
大阪大 微生物病研 病院
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鈴木 新治
Faculty Of Pharmaceutical Sciences Osaka University
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船津 由美子
Faculty Of Pharmaceutical Sciences Osaka University
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