Inhibition of Gluconeogenesis by Salicylate and 5-Methoxysalicylate in Liver of Normal and Alloxan-Diabetic Rats(Pharmaceutical)
スポンサーリンク
概要
- 論文の詳細を見る
Salicylate or 5-methoxysalicylate inhibited gluconeogenesis from L-lactate in the isolated, perfused liver of normal and alloxan-diabetic rats. No differences in the inhibitory actions were observed between normal and diabetic rats. The effects of both drugs were dependent on their concentrations in the medium and on the treatment periods. However, since neither salicylate nor 5-methoxysalicylate inhibited the gluconeogenesis from dihydroxyacetone or pyruvate, both drugs seem to inhibit a pathway from L-lactate to pyruvate, which is metabolized to triose phosphate.
- 公益社団法人日本薬学会の論文
- 1986-12-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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山崎 勝
Faculty of Pharmaceutical Sciences, Osaka University
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山崎 勝
大阪大学薬学部
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西畑 利明
大阪大学薬学部
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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西畑 利明
Faculty of Pharmaceutical Sciences, Osaka University
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須藤 真生
Faculty of Pharmaceutical Sciences, Osaka University
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須藤 真生
Faculty Of Pharmaceutical Sciences Osaka University
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