Inhibitory Effect of Clindamycin on Production of β-Lactamase in β-Lactam-Resistant Bacteria
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effect of clindamycin on β-lactamase biosynthesis was investigated in β-lactam resistant bacteria with inducible and/or constitutive production of the enzyme (s). Clinical isolates of Enterobacter cloacae (E. cloacae) and Pseudomonas aeruginosa (P. aeruginosa) were examined. Three strains of each, against which sulbactam at 8μg/ml reduced the minimum inhibitory concentration (MIC) of cefoperazone (CPZ) at least 4 fold, were studied in greater detail. Although clindamycin had no appreciable effect on bacteria growth at concentrations up to 50μg/ml, it suppressed inducible β-lactamase biosynthesis almost completely at a concentration of 20μg/ml. There was also a significant reduction of constitutive enzyme biosynthesis by clindamycin at 50 μg/ml. Thus, it was estimated that a high concentration of clindamycin was required to suppress β-lactamase biosynthesis in β-lactamase producing bacteria of the constitutive type.
- 公益社団法人日本薬学会の論文
- 1994-05-15
著者
-
西畑 利明
大阪大学薬学部
-
西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
-
国枝 幸代
Pharmacy Research, Upjohn Tsukuba Research Laboratories
-
中浜 力
Respiratory Internal Medicine Kawasaki Medical School
-
副島 林蔵
Respiratory Internal Medicine, Kawasaki Medical School
-
副島 林蔵
Respiratory Internal Medicine Kawasaki Medical School
-
国枝 幸代
Pharmacy Research Upjohn Tsukuba Research Laboratories
-
西畑 利明
Pharmaceutical Chemistry Department The University Of Kansas
関連論文
- サリチル酸ナトリウム,エチレンジアミン四酢酸ニナトリウム,及びポリオキシエチレン(23)ラウリルエーテルのセフォキシチンナトリウム直腸吸収促進効果の比較(発表論文抄録(1985年))
- エピネフリン代謝物によるセフメタゾール,セホキシチンのラット直腸吸収促進及びセファマイシン系抗生物質の高速液体クロマトグラフィーによる血中濃度の測定(発表論文抄録(1984年),福山大学開学10周年記念号)
- Evaluation of Enteric Coated Tablet Sensitive to Pancreatic Lipase. II. In Vivo Evaluation
- 第18回薬物代謝と薬効・毒性シンポジウム
- Effect of Water Extracts of Crude Drugs in Decreasing Blood Ethanol Concentrations in Rats(Pharmaceutical,Chemical)
- In Vitro Percutaneous Transport of Sodium Diclofenac and Diclofenac from Oleaginous Vehicle
- In Vitro Transport of Sodium Diclofenac across Rat Abdominal Skin : Effect of Selection of Oleaginous Component and the Addition of Alcohols to the Vehicle
- 水素添加レシチンとMethyl Palmitateにより作成した基剤からのNa Diclofenacの放出(発表論文抄録(1988年))
- Preparation of Controlled-Release Granules of Sodium Diclofenac(Pharmaceutical)
- Use of High Performance Liquid Chromatography for Increased Assay Sensitivity of β-Lactamase Activity in Bile
- Influence of Diethyl Maleate-Induced Loss of Thiols on Cefmetazole Uptake into Isolated Epithelial Cells and on Cefmetazole Absorption from Ileal Loop of Rats(Pharmaceutical)
- Effect of Diethyl Maleate and Sodium Salicylate on Cefmetazole Transport in the in Vitro Rat Everted Intestinal Sac : Influence of Ca^ and Vanadate in the Media(Pharmaceutical)
- Formation and Hydrolysis of Enamine in Aqueous Solution
- Effect of Extracts of Zingiberaceae Herbs on Gastric Secretion in Rabbits
- Effect of Water Extracts of Aloe and Some Herbs in Decreasing Bllod Ethanol Concentration in Rats. II.
- Glucose Release from Isolated, Perfused Liver of Alloxan-Diabetic Rats
- Intestinal Absorption of N, N'-Dimethylcarbamoylmethyl 4-(4-Guanidinobenzoyloxy) Phenylacetate Methanesulfonate in Rats
- Evaluation of Enteric Coated Tablet Sensitive to pancreatic Lipase. I. In Vitro Disintegration Test
- Use of Hydrogenated Soya Phospholipids as a Diluent : Preparation of Sustained-Release Tablets of Theophylline and Sodium Diclofenac(Pharmacological,Chemical)
- Enhancement of Rectal Absorption of Ampicillin by Sodium Salicylate in Rabbits
- Inhibitory Effect of Clindamycin on Production of β-Lactamase in β-Lactam-Resistant Bacteria
- Effect of 2,4-Dinitrophenol on Transport of Cefmetazole and Diclofenac from Thigh Muscle Tissue and from Intestinal Connective Tissue into Blood Circulation in Rats
- Inhibition of Gluconeogenesis by Salicylate and 5-Methoxysalicylate in Liver of Normal and Alloxan-Diabetic Rats(Pharmaceutical)
- Effect of Nonprotein Thiols in the Intestinal Tissue on the Transport of Salicylate
- Effect of Salicylate and Disodium Ethylenediaminetetraacetic Acid on the Rat Intestinal Absorption of Cefmetazole
- Enamine Formation of Various Amino Acids with Ethyl Acetoacetate in Aqueous Solution in Relation to Colonic Absorption of Cefmetazole
- Rectal Absorption of [Asu^]-Eel Calcitonin in Rats
- Rectal Absorption of Lysozyme and Heparin in Rabbits in the Presence of Non-surfactant Adjuvants
- Cefoxitinのラット小腸吸収に及ぼすTriglycerideの影響(発表論文抄録(1987年))
- ラットにおけるセフォキシチンナトリウムの腸管吸収 : 剤型の影響(発表論文抄録(1986年))
- Effect of Salicylate on the Binding of Sulfonamides to Bovine Serum Albumin
- Study of Enamine Derivatives of Phenylglycine as Adjuvants for the Rectal Absorption of Insulin
- ウリカーゼ活性に及ぼす4-Hydroxypyrazolo[3,4-d]pyrimidineの影響
- Role of Acetone Bodies in the Abnormal Pharmacokinetic Behavior of Chlorpropamide in Alloxan Diabetic Rabbits
- On the Mechanism of Increased Renal Tubular Reabsorption of Drugs in Alloxan Diabetic Rabbits
- Pharmacokinetic Behavior of Chlorpropamide and Sulfadimethoxine in Alloxan Diabetic Rabbits
- Blood Chemistry in Alloxan Diabetic Rabbits
- Pharmacokinetic Behavior of Sulfamethoxazole in Alloxan Diabetic Rabbits