Studies on Absorption of Drugs. IV. Effects of Surface Active Agents on Intestinal Absorption of Drugs
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概要
- 論文の詳細を見る
Effects of surface active agents (ionic and nonionic) on intestinal absorption of drugs were studied on three method, i. e., (1) circulation with surfactants, (2) preperfusion with surfactant solutions, followed by circulation of drug solution free from surfactants, and (3) feeding experiments of surfactants solutions, followed by circulation of drug solution. Effects of surfactants were reviewed from two points. One is the effect due to interaction of drugs with surfactants and the other effect due to degeneration of the intestinal mucosa. It is concluded that the absorption of ionized species of drugs were more decreased than that of unionized species in degenerated intestinal mucosa, except for ionic interaction between drugs and surfactants.
- 社団法人日本薬学会の論文
- 1969-06-25
著者
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青木 大
Faculty Of Pharmaceutical Sciences Osaka University
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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矢田 登
Faculty of Pharmaceutical Sciences, Osaka University
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岸本 浩一
Faculty of Pharmaceutical Sciences, Osaka University
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麦野 智恵子
Faculty of Pharmaceutical Sciences, Osaka University
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坂口 博道
Faculty of Pharmaceutical Sciences, Osaka University
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田部 和久
Faculty of Pharmaceutical Sciences, Osaka University
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三村 伊代子
Faculty of Pharmaceutical Sciences, Osaka University
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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田部 和久
大阪大学微生物病研究所附属病院薬剤部
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田部 和久
関西労災病院
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田部 和久
Faculty Of Pharmaceutical Sciences Osaka University
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三村 伊代子
Faculty Of Pharmaceutical Sciences Osaka University
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坂口 博道
Faculty Of Pharmaceutical Sciences Osaka University
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岸本 浩一
Faculty Of Pharmaceutical Sciences Osaka University
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麦野 智恵子
Faculty Of Pharmaceutical Sciences Osaka University
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