Influence of Administration Routes of Sodium Ampicillin on the Cecal Flora in Rats : Role of Biliary Excretion

概要

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The role of biliary excretion of sodium ampicillin (ABPC Na) was studied in relation to the influence of drug administration routes on the cecal flora in rats. When ABPC Na was administered intravenously, orally or rectally to normal rats, populations of bacteria such as Enterobacteriaceae, Streptococci, Staphylococci, and Bacteroidaceae in the cecal contents decreased by a factor of 10 to 100 at 9 h after administration. However, the changes of the cecal flora by ABPC Na were not influenced by the administration routes. To investigate the role of biliary excretion of ABPC Na intravenous administration to bile-fistula rats was performed. However, in the absence of bile in the intestinal lumen, the bacterial populations in the cecal contents were markedly modified even in rats without drug treatment. Therefore, the influence of biliary excretion of ABPC Na on the cecal flora was investigated using bile-supplied bile-fistula rats. When ABPC Na was given orally to these bile-supplied bile-fistula rats, Enterobacteriaceae, Streptococci, and Staphylococci decreased markedly. On the other hand, when ABPC Na was given intravenously, changes in the cecal flora were not observed. These observations suggest that antibiotics which show low biliary excretion will have little effect on the intestinal flora if administered intravenously or rectally.
社団法人日本薬学会の論文
1984-10-25