Influence of Bile on the Gastrointestinal Absorption of Phenytoin in Rats
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概要
- 論文の詳細を見る
The influence of endogeneous bile on the gastrointestinal absorption of phenytoin (DPH) was studied in rats after oral administration of DPH as an aqueous or oil suspension. A bile salt such as sodium taurocholate considerably enhanced DPH dissolution and solubility. The bioavailability of DPH from aqueous suspension was significantly lower in bile duct-ligated rats than in control or sham-operated animals. When DPH was administered to bile duct-ligated rats as a sesame oil suspension, its maximum blood concentration was significantly lower than that in sham-operated rats. These results suggest that endogenous bile plays an important role in the dissolution of DPH and the emulsification or dispersion of oil in the gastrointestinal tract. After laparotomy, DPH administered with vehicles of high viscosity, such as sesame oil, showed significantly delayed absorption but increased bioavailability.
- 公益社団法人日本薬学会の論文
- 1985-11-25
著者
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水野 亘恭
Faculty of Pharmaceutical Sciences, Osaka University
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水野 亘恭
武庫川女子大学薬学部
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新熊 傳治
兵庫医科大
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山中 要
兵庫医科大
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矢田 登
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Hamaguchi T
Department Of Pharmacy Hyogo College Of Medicine
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新熊 傳治
Department of Pharmacy, Hyogo College of Medicine
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山中 要
Department of Pharmacy, Hyogo College of Medicine
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浜口 常男
Department of Pharmacy, The Hospital of Hyogo College of Medicine
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浜口 常男
Department Of Pharmacy Hyogo College Of Medicine
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水野 亘恭
武庫川女子大・薬
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水野 亘恭
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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