Method for Determination of Partition Coefficients by High-Performance Liquid Chromatography on an Octadecylsilane Column. Examination of Its Applicability

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概要

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• The high-performance liquid chromatography (HPLC) of various compounds on an ODS (octadecylsilane) stationary phase was carried out with mobile phases containing vaious amounts of organic solvents, and the retention behavior was analyzed in terms of the partition coefficient between octanol and water P<oct>. It was found that the capacity factor k' increased linearly with P_<oct>. However, this relation was dependent on the hydrogen-bonding ability of the compounds. The retention behaviors of non-hydrogen bonders, hydrogen acceptors and amphiprotic compounds were different.It was shown that from the results of HPLC on an ODS column, values of P_<oct> of various compounds can be determined accurately and simply, by a single equation, when the hydrogen-bonding property of the compounds is take into account. The accuracy of the estimated P_<oct> value increased with decrease in the concentration of the organic solvent in the mobile phase.

• 社団法人日本薬学会の論文
• 1986-11-25

著者

• 水野 亘恭

  Faculty of Pharmaceutical Sciences, Osaka University

• 寺田 弘

  Faculty of Pharmaceutical Sciences, University of Tokushima

• 寺田 弘

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 三宅 [ケイ]司郎

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• 寺田 弘

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 三宅 司郎

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• 水野 亘恭

  Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• 三宅 [ケイ]司郎

  Faculty of Pharmaceutical Sciences, Mukogawa Women's University

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