Increase in Water Permeability of Negatively Charged Liposomal Membrane by Local Anesthetics
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概要
- 論文の詳細を見る
Effect of the local anesthetics dibucaine, tetracaine, lidocaine and procaine on the water permeability of phospholipid membrane was examined using liposomes composed of bovine heart cardiolipin and egg yolk phosphatidylcholine in a molar ratio of 2/98 by monitoring the osmotic shrinkage of liposomes in hypertonic glucose solution at pH 7.3 and 30℃. These local anesthetics greatly accelerated the water permeability by destabilizing the membrane structure. The effect was found to be governed by the hydrophobicity of the anesthetics. There was also a significant correlation between the membrane destabilizing actions and the anesthetic activities.
- 社団法人日本薬学会の論文
- 1992-07-25
著者
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寺田 弘
Faculty of Pharmaceutical Sciences, University of Tokushima
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寺田 弘
Faculty Of Pharmaceutical Sciences University Of Tokushima
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瀬戸 小百合
Faculty Of Pharmaceutical Sciences University Of Tokushima
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下岡 尚
Faculty of Pharmaceutical Sciences, University of Tokushima
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下岡 尚
Taiho Pharmaceutical Co., Ltd.
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寺田 弘
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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下岡 尚
Taiho Pharmaceutical Co. Ltd.
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