Transcellular Permeation of Nitrophenols through Newborn Rat Skin Epidermal Cells in Monolayer Culture
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概要
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The permeation of nitrophenols through epidermal cells from newborn rat skin cultured on type IV collagen-coated Millipore filters was studied under various conditions. The order of permeation through the cultured skin cells was found to be p->m->o-nitrophenol at both 10 and 37℃. This order was the same as that of their affinities to isolated skin cells. The permeation of nitrophenols was not inhibited by the inhibitors of energy transduction 2-deoxyglucose and NaN_3. These results suggest that the permeation of nitrophenols across a cultured cell layer occurs by simple diffusion. The order of permeation of nitrophenols across newborn abdominal epidermis was exactly the opposite of that of their permeation across a cultured cell layer.
- 1990-10-25
著者
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寺田 弘
Faculty of Pharmaceutical Sciences, University of Tokushima
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寺田 弘
Faculty Of Pharmaceutical Sciences University Of Tokushima
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大倉 一人
Faculty of Pharmaceutical Sciences, University of Tokushima
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岩本 清美
Faculty of Pharmaceutical Sciences, University of Tokushima
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大倉 一人
Faculty Of Pharmaceutical Sciences University Of Tokushima
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寺田 弘
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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岩本 清美
Faculty Of Pharmaceutical Sciences University Of Tokushima
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