Centrifugal Partition Chromatography(CPC) as a Useful Method for Determination of Partition Coefficients between Octanol and Water(Analytical,Chemical)

概要

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Centrifugal partition chromatographies(CPC) of three series of compounds, phenols, benzoic acids and N-phenylanthranilic acids, were performed with acetonitrile as a mobile phase and n-hexane as a stationary phase. Values for the partition coefficient (P_<cpc>) of these compounds were determined from the ratio of their concentration in the n-hexane phase to that in the acetonitrile phase, and they were compared with the partition coefficient between octanol and water determined by the shaking-flask method (P_<oct>). A significant linear relation was obtained between log P_<cpc> and log P_<oct> for each series of compounds up to log P_<oct> values of about 6, indicating that CPC is a very useful method for simple and accurate determination of P_<oct>.
社団法人日本薬学会の論文
1987-12-25