ジブカイン塩基の物理化学的性質および作用性に及ぼす対イオンの影響に関する研究(第3報) : 蛙坐骨神経の興奮伝導遮断作用と親媒性に及ぼす影響
スポンサーリンク
概要
- 論文の詳細を見る
Effects of counter ions on the onset time, effective duration, and half-blocking concentration of dibucaine base were evaluated by the method described previously. They were also reviewed in reference to the ratio and rate of distribution between chloroform and water, the rate of permeation through the cellophane membrane, and the rate of diffusion in water were additionally pursued. A certain relationship was found between the ratio of distribution and half-blocking concentration, as was the case between the rate of distribution and onset time or effective duration.
- 公益社団法人日本薬学会の論文
- 1966-09-25
著者
-
青木 大
Faculty Of Pharmaceutical Sciences Osaka University
-
青木 大
大阪大学薬学部薬剤学教室
-
矢田 登
大阪大学薬学部薬剤学教室
-
矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
関連論文
- Studies on Absorption of Drugs. VI. Effects of Buffer Components on the Absorption of Drugs
- Biological Activity of Drugs. XI. Relation of Structure to the Bacteriostatic Activity of Sulfonamides. (2)
- Biological Activity of Drugs. X. Relation of Structure to the Bacteriostatic Activity of Sulfonamides. (1)
- Biological Activities of Drugs. IX. Structure-Activity Relationship of Sulfonamide Carbonic Anhydrase Inhibitors.
- Application of Surface Active Agents to Pharmaceutical Preparations. XV. Factors Affecting on the Preparation of Oil-in-Water Emulsion. (1). A New Determination of a Required HLB and an Adaptability of Surfactants to Oils
- Biological Activities of Drugs. VIII. Structure-Activity Relationship of Sulfonamide Carbonic Anhydrase Inhibitors. (3)
- Studies on Fatty Acid Esters of Pyridoxine. VI. Effects of Surfaceactive Agents on the Gastro-intestinal Absorption of Pyridoxine 3,4-Dipalmitate in Man
- Biological Activities of Drugs. VII. Structure-Activity Relationship of Sulfonamide Carbonic Anhydrase Inhibitors. (2)
- Studies on Pharmaceutical Suspension. IV. Flocculation of Dispersed Phase and Structural Viscosity
- Studies on Absorption of Drugs. IV. Effects of Surface Active Agents on Intestinal Absorption of Drugs
- Biological Activities of Drugs. VI. Structure-Activity Relationship of Sulfonamide Carbonic Anhydrase Inhibitors. (1)
- Studies on Fatty Acid Esters of Pyridoxine. II. Percutaneous Absorption of Pyridoxine and Its Derivatives
- ピリドキシン脂肪酸エステルの薬剤学的研究 : (VII)PyridoxineおよびPyridoxine 3,4-dioctanoateの経皮吸収(2)経皮吸収におよぼす基剤の影響
- ピリドキシン脂肪酸エステルの薬剤学的研究 : (V)数種エステルの人における消化管吸収
- ピリドキシン脂肪酸エステルの薬剤学的研究 : (IV)シロネズミの反転腸管による各種ピリドキシン脂肪酸エステルの消化管吸収
- ピリドキシン脂肪酸エステルの薬剤学的研究 : (III)Pyridoxine 5-octanoateの合成および物理化学的性質
- 127.ピリドキシン脂肪酸エステルの薬剤学的研究(IV) : 消化管吸収(一般研究発表要旨)
- Biological Activities of Drugs. IV. Physicochemical Factors Affecting the Excretion of Sulfonamides in Rats
- Biological Activities of Drugs. III. Physicochemical Factors Affecting the Excretion of Sulfonamides in Rabbits
- 粉末薬剤の滑沢化について(第6報) : 炭酸水素ナトリウムにステアリン酸マグネシウムを加えた際にみられる流動化の機構について
- Pharmacokinetics in Hepatic Transport of Amaranth in Rats Intoxicated with Carbon Tetrachloride and α-Naphthylisothiocyanate
- The Absorption of Organomercurial Compounds from the Vaginal Route of the Rabbits. II. Distribution and Excretion of ω-Ethylmercurithio-n-undecanoic Acid and Phenylmercuric Acetate.
- The Absorption of Organomercurial Compounds from the Vaginal Route of the Rabbits. I. Comparative Study on the Effect of Suppository Vehicles on the Absorption of ω-Ethylmercurithio-n-undecanoic Acid, Phenylmercuric Acetate and Ethylmercuric Chloride afte
- Plasma α_1-Acid Glycoprotein Concentration in Rats with Chemical Liver Injury
- Application of Microdialysis for Study of Caffeine Distribution into Brain and Cerebrospinal Fluid in Rats
- Application of Photoacoustic Microscopy to Analysis of Biological Components in Tissue Sections
- LASER PHOTOACOUSTIC MICROSCOPY FOR THE DETERMINATION OF DYE ON A SOLID BIOPOLYMER
- Influence of Administration Routes of Sodium Ampicillin on the Cecal Flora in Rats : Role of Biliary Excretion
- Effect of Bile Salts on the Rectal Absorption of Sodium Ampicillin in Rats
- Influence of Administration Routes of Antibiotics on the Cecal Flora in Rats. I
- Effect of Isoxazolyl-penicillin on the Rectal Absorption of Ampicillin in Rabbits and Humans
- Studies of Absorption Promoters for Rectal Delivery Preparations. II. A Possible Mechanism of Promoting Efficacy of Enamine Derivatives in Rectal Absorption
- Saponins from Chinese Cucurbitaneous Plants : Solubilization of Saikosaponin-a with Hemslosides Ma2 and Ma3 and Structure of Hemsloside H_1 from Hemsleya chinensis
- Stability of p-Hydroxybenzoic Acid Esters in an Acidic Medium
- Effect of Humidity Aging on Disintegration, Dissolution and Cumulative Urinary Excretion of Calcium p-Aminosalicylate Formulations(Pharmaceutical)
- Studies on Absorption of Drugs. VII. Absorption of Isomeric N^1-Heterocyclic Sulfonamides from the Rat Small Intestines and Relations between Physicochemical Property and Absorption of Unionized Sulfonamides
- Studies on Absorption of Drugs. VIII. Physicochemical Factors affecting the Absorption of Sulfonamides from the Rat Small Intestine
- Influence of Bile on the Gastrointestinal Absorption of Phenytoin in Rats
- Comparison of the Effects of Sesame Oil and Oleic Acid as Suspension Vehicles on Gastrointestinal Absorption of Phenytoin in Rats
- Influence of Vehicle on Gastrointestinal Absorption of Phenytoin in Rats
- Effect of 2,4-Dinitrophenol on Transport of Cefmetazole and Diclofenac from Thigh Muscle Tissue and from Intestinal Connective Tissue into Blood Circulation in Rats
- Biopharmaceutical Study of Pyrithioxin following Oral and Intravenous Administration to Dog
- Blood Concentration and Urinary Excretion Profiles following Oral Administration of Esters of Pyrithioxin to Dogs
- Determination of Pyrithioxin and Its Metabolites in Blood and Urine of Dogs by High-Performance Liquid Chromatography
- Biopharmaceutical Study on the Oral and Rectal Administrations of Enamine Prodrugs of Amino Acid-like β-Lactam Antibiotics in Rabbits
- Effect of Salicylate on the Binding of Sulfonamides to Bovine Serum Albumin
- Effect of Salicylate on the Metabolism and Urinary Excretion of Sulfonamides in the Rat
- Effect of Salicylate on the Blood Concentration Profile and Distribution of Sulfonamides in Rat
- Effect of Salicylate on the Distribution of Sulfonamides to Red Blood Cells in Rat
- Study of Enamine Derivatives of Phenylglycine as Adjuvants for the Rectal Absorption of Insulin
- Studies on Absorption Promoters for Rectal Delivery Preparations. I. Promoting Efficacy of Enamine Derivatives of Amino Acids for the Rectal Absorption of β-Lactam Antibiotics in Rabbits
- Saponins of Pericarps of Sapindus mukurossi GAERTN. and Solubilization of Monodesmosides by Bisdesmosides
- Interaction of Saponin of Bupleuri Radix with Ginseng Saponin : Solubilization of Saikosaponin-a with Chikusetsusaponin V (=Ginsenoside-Ro)
- Solubilizing Properties of Saponins from Sapindus mukurossi GAERTN.
- Role of Acetone Bodies in the Abnormal Pharmacokinetic Behavior of Chlorpropamide in Alloxan Diabetic Rabbits
- On the Mechanism of Increased Renal Tubular Reabsorption of Drugs in Alloxan Diabetic Rabbits
- Pharmacokinetic Behavior of Chlorpropamide and Sulfadimethoxine in Alloxan Diabetic Rabbits
- 界面活性剤の製剤への応用研究(第14報) : 非イオン性界面活性剤による乳化系の転相温度に関する研究その3 添加成分の影響
- 界面活性剤の製剤への応用研究(第13報) : 非イオン性界面活性剤による乳化系の転相温度に関する研究その2 転相温度の支配要因
- Blood Chemistry in Alloxan Diabetic Rabbits
- Pharmacokinetic Behavior of Sulfamethoxazole in Alloxan Diabetic Rabbits
- "生体に密着した薬"の知識("薬学の基礎"の概念)
- ジブカイン塩基の物理化学的性質および作用性に及ぼす対イオンの影響に関する研究(第4報) : ジブカイン塩基の蛋白結合に及ぼす影響
- ジブカイン塩基の物理化学的性質および作用性に及ぼす対イオンの影響に関する研究(第3報) : 蛙坐骨神経の興奮伝導遮断作用と親媒性に及ぼす影響
- ジブカイン塩基の物理化学的性質および作用性に及ぼす対イオンの影響に関する研究(第2報) : 蛙坐骨神経を使用した, 作用時間および作用強度の測定法について
- ジブカイン塩基の物理化学的性質および作用性に及ぼす対イオンの影響に関する研究(第1報) : 親媒性と表面麻痺作用に及ぼす影響