Biological Activities of Drugs. III. Physicochemical Factors Affecting the Excretion of Sulfonamides in Rabbits
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概要
- 論文の詳細を見る
Blood levels of 14 sulfonamides in rabbits subjected to intravenous administration were found to decrease following a first-order rate. The rate constants for acetylation and excretion were estimated from the first-order half-life in blood and the degree of acetylation in urine. Relationship between physicochemical properties of sulfonamides and rates of excretion was discussed. Binding of sulfonamides with plasma protein was scarcely correlated with the excretion rate. Rate constant of excretion, k_3,was closely correlated with partition coefficients between chloroform and a buffer solution of pH 8.8.
- 社団法人日本薬学会の論文
- 1968-04-25
著者
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青木 大
Faculty Of Pharmaceutical Sciences Osaka University
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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山崎 勝
Faculty of Pharmaceutical Sciences, Osaka University
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山崎 勝
大阪大学薬学部
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