透析チューブ法によるレクタルカプセル剤からの薬物放出試験

概要

論文の詳細を見る
The release of indomethacin from 3 kinds of rectal capsules was investigated by 2 different dialysis tubing methods, i.e., stationary method and up-and-down motion method. In the case of stationary method, any release rate of indomethacin from rectal capsules was much slower than that from suppositories, and the amount of the release during 2 hrs was within 8% of the labeled amount. The release of the drug from rectal capsule was not improved by the addition of water into the dialysis tubing, or by sinking deeply the dialysis tubing to spread out the contents in rectal capsule. However, by the up-and-down motion of dialysis tubing using disintegration test apparatus, the release rate was 2-3 times higher than that by the stationary method. The data from this experimental condition was well reproducible. The technique could be applied to test the release of drug from both rectal capsule and suppository.
日本医療薬学会の論文
1988-08-20