Biological Activity of Drugs. X. Relation of Structure to the Bacteriostatic Activity of Sulfonamides. (1)
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概要
- 論文の詳細を見る
Based on the experimental observations that the concentrations of ionized and unionized molecules of sulfonamides at the bacteriostatis are linearly related to the drug's pK_a, equations of the relation of pK_a to bacteriostatic activity of sulfonamides against Escherichia coli are proposed. The optimal acid dissociation constant, pK_a^0,of sulfonamides which are active at a minimum concentration is calculated. pK_a^0 and the minimum bacteriostatic concentration are found to change with changes of pH of culture media.
- 社団法人日本薬学会の論文
- 1970-04-25
著者
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青木 大
Faculty Of Pharmaceutical Sciences Osaka University
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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森下 孝
Faculty of Pharmaceutical Sciences, Osaka University
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山崎 勝
Faculty of Pharmaceutical Sciences, Osaka University
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掛谷 宣治
Faculty of Pharmaceutical Sciences, Osaka University
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山崎 勝
大阪大学薬学部
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森下 孝
Faculty Of Pharmaceutical Sciences Osaka University
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掛谷 宣治
Research Laboratories Kyoto Pharmaceutical Industries Ltd.
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