Effect of Salicylate on the Metabolism and Urinary Excretion of Sulfonamides in the Rat

概要

論文の詳細を見る
The effect of concomitant administration of salicylate on the acetylation and urinary excretion of sulfonamides (sulfanilamide, sulfamethoxazole, sulfadiazine, sulfisoxazole and sulfathiazole) after intravenous administration to rats was studied. The degree of acetylation of sulfamethoxazole in rat urine was found to be significantly decreased by salicylate treatment, but that of sulfathiazole was increased. It was previously found that the eliminations of sulfamethoxazole and sulfathiazole from rat blood were markedly reduced by the concomitant administration of salicylate. To reconcile these apparently conflicting effects of salicylate treatment on the fate of the two sulfonamides, urine samples were collected at intervals and the rate constant of urinary excretion and that of acetylation were calculated employing the elimination rate constant from rat blood. The decrease in the elimination of sulfamethoxazole on salicylate treatment was explained on the basis of a decrease in the acetylation rate constant. However, for sulfathiazole, the decrease in the elimination was a result of a decrease in the excretion rate constant due to the inhibitory effect of salicylate treatment on the excretion of unchanged sulfathiazole.
公益社団法人日本薬学会の論文
1979-08-25