The Absorption of Organomercurial Compounds from the Vaginal Route of the Rabbits. II. Distribution and Excretion of ω-Ethylmercurithio-n-undecanoic Acid and Phenylmercuric Acetate.

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The excretion and tissue distribution of ω-ethylmercuri (Hg^<203>)-thio-n-undecanoic acid (EMU) after vaginal administration were pursued in comparison with phenylmercuric (Hg^<203>)-acetate (PMA). PMA was excreted into feces and urine twice as much as EMU when a Carbowax 2000 suppository was employed. The excretion of EMU was almost equal irrespective of the use of Carbowax 2000 or Rx 6 (emulsion vehicle containing stearic acid). A decrease in total excretion of PMA by the use of the emulsion vehicle was observed over a Carbowax 2000 vehicle. The decrease would indicate a decrease in absorption due to a change of PMA into more lipophilic stearate. Cumulative excretion of PMA after repeated daily administrations showed a linear relationship, but in the case of EMU, a more increase of excretion was observed, showing a correspondence with the accumulation in tissue. Both PMA and EMU showed a high mercury storage in the liver and kidneys. A comparative study was made of the amounts and rates of mercurials excreted following a single intravenous administration. The excretion of mercurial into the urine following intravenous administration of the mercurials was higher or not less than vaginal application. Acceleration of mercurial excretion was observed when BAL or α-lipoic acid was given simultaneously with insertion of a suppository containing mercurials.
社団法人日本薬学会の論文
1964-05-25