Application of Surface Active Agents to Pharmaceutical Preparations. XV. Factors Affecting on the Preparation of Oil-in-Water Emulsion. (1). A New Determination of a Required HLB and an Adaptability of Surfactants to Oils

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The present paper deals with a new method to determine a required HLB of oil and an adaptability of surfactants to oils. Measurements were made of a continuous change of viscosity and electric conductivity during emulsification. The viscosity was measured with a torque meter equipped to the upper part of a stirring shaft. There was found a characteristic change at the stage of phase inversion. Plotting the highest viscosity in a phase inversion vs. HLB of combined surfactants showed two peaks with a depressed junction. Temperature range for phase inversion showed a similar pattern in reference to HLB. The middle HLB of the junction was assumed to be a required HLB. The required HLB was also confirmed with small and uniform particle size and good stability on aging at 30°. And surfactants suitable for oils may be selected on the basis of relations between the highest viscosity during phase inversion and HLB of combined surfactants. The present paper deals also with the phase inversion temperature in reference to HLB of combined surfactants.
社団法人日本薬学会の論文
1970-01-25