4-アミノ-5-ヒドロキシメチルピリミジンのチアミン生合成中間体としての可能性の検討

概要

論文の詳細を見る
It has been proposed by several groups of investigators that the pyrimidine moiety of thiamin is synthesized via 5-aminoimidazole ribotide, an intermediate of purine biosynthetic route in bacteria. To decide whether the methyl group attached to C-2 atom of the pyrimidine is introduced after the recyclization of the imidazole ring of 5-amino-imidazole ribotide (AIR) to the pyrimidine, the competition of radioactive formate incorporation into the pyrimidine moiety by 4-amino-5-hydroxy-methylpyrimidine was investigated. The results showed that this compound was not used as a biosynthetic intermediate by Escherichia coli and Saccharomyces cerevisiae. It remains unsolved, at which step methyl group is introduced and which compound is methyl origin of the pyrimidine moiety of thiamin.
日本ビタミン学会の論文
1981-01-25