Synthesis of Peptide Chloromethyl Ketones and Examination of Their Inhibitory Effects on Human Spleen Fibrinolytic Proteinase (SFP) and Human Leukocyte Elastase (LE)(Organic,Chemical)

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概要

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• Various substrate-derived chloromethyl ketones were synthesized by a conventional method for the purpose of obtaining specific and potent irreversible inhibitors for human spleen fibrinolytic proteinase (SFP) and human leukocyte elastase (LE) in order to compare the properties of SFP with those of LE. It was found that Boc-Ala-Tyr-Leu-Val-CH_2Cl among the peptide chloromethyl ketones exhibited the most effective and specific inhibition of SFP and LE. The two enzymes were inhibited by peptide chloromethyl ketones having a Val residue at the C-terminus in a similar manner, demonstrating a similarity between SFP and LE.

• 公益社団法人日本薬学会の論文
• 1987-09-25

著者

• TSUDA Yuko

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• OKADA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Nagamatsu Y

  Kobe‐gakuin Univ. Kobe Jpn

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Okada Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• NAGAMATSU Yoko

  Faculty of Phamaceutical Sciences

• OKAMOTO UTAKO

  Faculty of Nutrition, Kobe-Gaukin University

• OKAMOTO Utako

  Kobe Research Projects on Thrombosis and Haemostasis

• Nakaya Y

  Kobe Research Projects On Thrombosis And Haemostasis

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