Syntheses of 1-(p-Nitrophenyl)-3-(2,2-dichloroacetamido)-1,2-propanediols.
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概要
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2-Bromo-3-acetoxyropiophenone (VI) was reacted with potassium phthalimide in dimethylformamide to give 2-acetoxy-3-phthalimidopropiophenone (XI). XI was submitted to hydrogenation over palladium on charcoal followed by acetylation with acetic anhydride and pyridine to yield two DL-isomers of 1-phenyl-3-phthalimide-1,2-propanediol diacetate (XIII). Two DL-isomers of 1-(p-nitrophenyl)-3-(2,2-dichloroacetamido)-1,2-propanediol (I), the position isomers of chloramphenicol, were derived from XIII.
- 公益社団法人日本薬学会の論文
- 1966-05-25
著者
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名川 方敏
Central Research Laboratories Sankyo Co. Ltd.
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伊藤 博雄
三共中央研究所
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寺田 敦祐
Central Research Laboratories, Sankyo Co., Ltd.
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寺田 敦祐
京都薬科大学 化学研究所
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伊藤 博雄
Central Research Laboratories, Sankyo Co., Ltd.
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