Studies on 1,3-Benzoxazines. VI. Formation of Quinazolines and 4H-3,1-Benzoxazines by the Reaction of 4-Chloro-2H-1,3-benzoxazines with Aminoacetophenone, Aminobenzophenone and Aminobenzyl Alcohol Derivatives
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概要
- 論文の詳細を見る
A novel synthetic method for quinazoline and 4H-3,1-benzoxazine derivatives is described. Reaction of 4-chloro-2H-1,3-benzoxazine (1) with 2-aminoacetophenone (2a) gave rise to the quinazoline derivative (4a) in good yield, while treatment of aminobenzophenones (2b-e) with 1 afforded only substituted compounds (3b-e), which could be converted into quinazoline derivatives (4b-e) on heating in the presence of p-toluenesulfonic acid in toluene. Derivatives of 4H-3,1-benzoxazines (10a-e) were prepared by the reaction of the aminobenzyl alcohols (7a-e) with 1. A possible mechanism for the formation of these reaction products is discussed.
- 公益社団法人日本薬学会の論文
- 1982-02-25
著者
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太刀川 隆治
Central Research Laboratories, Sankyo Co., Ltd.
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太刀川 隆治
Central Research Laboratories Sankyo Co. Ltd.
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寺田 敦祐
Central Research Laboratories, Sankyo Co., Ltd.
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和智 一之
京都薬科大学 化学研究所
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寺田 敦祐
京都薬科大学 化学研究所
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和智 一之
Central Research Laboratories, Sankyo Co., Ltd.
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Terada A
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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