Reactions of Chlordiazepoxide and Diazepam N-Oxide with Dimethyl Acetylenedicarboxylate with Rearrangement to Quinoxaline Derivatives and X-Ray Analysis of a Resultant Tetracyclic Compound

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概要

• 論文の詳細を見る

• Three 1,4-benzodiazepine N-oxides, diazepam N-oxide (IIIa), nordiazepam N-oxide (IIIb) and chlordiazepoxide (IV) were submitted to 1,3-dipolar cycloaddition reaction with dimethyl acetylenedicarboxylate to give quinoxaline derivatives (Va from IIIa ; Vb from IIIb ; XI and XII from IV). It is likely that the cycloaddition reactions involve the rearrangement of Beckmann type in which initially formed adducts (i.e., VIa) rearrange to quinoxaline derivatives (i.e., VIIa). The structural determination of XII was made by X-ray crystallographic analysis.

• 社団法人日本薬学会の論文
• 1977-12-25

著者

• 宮寺 哲男

  Central Research Laboratories, Sankyo Co., Ltd.

• 太刀川 隆治

  Central Research Laboratories, Sankyo Co., Ltd.

• 田村 千尋

  Central Research Laboratories Sankyo Co., Ltd.

• 畠 忠

  Central Research Laboratories, Sankyo Co., Ltd.

• 太刀川 隆治

  Central Research Laboratories Sankyo Co. Ltd.

• 宮寺 哲男

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 川野 洋一

  Central Research Laboratories, Sankyo Co., Ltd.

• 川野 洋一

  Central Research Laboratories Sankyo Co. Ltd.

• 畠 忠

  Central Research Laboratories Sankyo Co. Ltd.

• 宮寺 哲男

  Chemical Research Laboratories Sankyo Co. Ltd.

• 田村 千尋

  Central Research Laboratories Sankyo Co. Ltd.

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