Synthetic Study of Siccanin, an Antifungal Antibiotic. II. An Attempt to Synthesis of Siccanin Skeleton

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概要

• 論文の詳細を見る

• A synthesis of a perhydrobenzo[a]xanthene related to the skeleton of siccanin (3), an antifungal antibiotic, was described. A series of reactions starting from Δ^<1(9)>-octal-2-one (5) gave 1-(2-hydroxy-6-methoxy-4-methylbenzyl)-2-methylene-9-vinyl-cis-decalin (19), whose acid-catalysed cyclization reaction yielded a perhydrobenzo[a]xanthene (20a) with cis/anti/cis ring junctures. The structure of the latter compound was determined by three dimensional X-ray analysis of its brosyl derivative (20c)

• 社団法人日本薬学会の論文
• 1972-12-25

著者

• 大木 英二

  Central Research Laboratories, Sankyo Co., Ltd.

• 老田 貞夫

  Central Research Laboratories, Sankyo Co., Ltd.

• 大橋 芳彦

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Chemical Research Laboratories Sankyo Co. Ltd.

• 大橋 芳彦

  Central Research Laboratories Sankyo Co. Ltd.

• 田村 千尋

  Central Research Laboratories Sankyo Co., Ltd.

• 大木 英二

  Research Laboratory Zenyaku Kogyo Co. Ltd.

• 大木 英二

  Central Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 田村 千尋

  Central Research Laboratories Sankyo Co. Ltd.

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