Studies on Bi-heterocyclic Compounds. I. 6-Substituted Dihydro-1,4-thiazinones(Organic,Chemical)
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概要
- 論文の詳細を見る
Reactions of 5-inethyl-2H-1,4-thiazin-3(4H)-one (4) with various N-acylpyridinium salts (7a-g) led to (N-acyldihydropyridyl)thiazinones (5a-g), oxidation of which yielded a new class of pyridylthiazinones (6a-g). These reactions were applied to the synthesis of other azaarylthiazinones. Some of these azaarylthiazinones, particularly 6-(4-pyridyl)thiazinones (6a, 14a and 14b) showed positive inotropie activity with little chronotropic effect on guinea pig left atria.
- 社団法人日本薬学会の論文
- 1987-06-25
著者
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高瀬 宗章
Research Laboratory of Zen-Yaku Kogyo Co., Ltd.
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大木 英二
Research Laboratory Zenyaku Kogyo Co. Ltd.
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山崎 宏亮
Research Laboratory, Zenyaku Kogyo Co. Ltd.,
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原田 秀範
Research Laboratory, Zenyaku Kogyo Co. Ltd.,
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松崎 憲一
Research Laboratory, Zenyaku Kogyo Co. Ltd.,
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吉岡 君友
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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吉岡 君友
Research Laboratory Zenyaku Kogyo Co. Ltd.
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高瀬 宗章
Research Laboratory Zenyaku Kogyo Co. Ltd.
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山崎 宏亮
Research Laboratory Zenyaku Kogyo Co. Ltd.
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原田 秀範
Research Laboratory Zenyaku Kogyo Co. Ltd.
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松崎 憲一
Research Laboratory Zenyaku Kogyo Co. Ltd.
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高瀬 宗章
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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