2-(Alkylthio) penem-3-carboxylic Acids. II. Chemical Manipulation of Penem Side Chains

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概要

• 論文の詳細を見る

• The tert-butyldimethylsilyl group was found to be effective for protection of the hydroxyl group in penem synthesis. Manipulation of the side-chain hydroxyl group of base-sensitive penem-3-carboxylates was successfully conducted by means of a displacement reaction using a combination of triphenylphosphine-diethyl azodicarboxylate in the presence of a nucleophile.

• 社団法人日本薬学会の論文
• 1980-11-25

著者

• 大木 英二

  Central Research Laboratories, Sankyo Co., Ltd.

• 老田 貞夫

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Chemical Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,

• 林 輝雄

  Chemical Research Laboratories Sankyo Co. Ltd.

• 大木 英二

  Research Laboratory Zenyaku Kogyo Co. Ltd.

• 大木 英二

  Central Research Laboratories Sankyo Co. Ltd.

• 林 輝雄

  Central Research Laboratories, Sankyo Co., Ltd.

• 武田 憲子

  Central Research Laboratories, Sankyo Co., Ltd.

• 武田 憲子

  Medical Chemistry Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

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