Triazole Antifungals. IV. Synthesis and Antifungal Activities of 3-Acylamino-2-aryl-2-butanol Derivatives

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概要

• 論文の詳細を見る

• New triazole compounds were designed and synthesized as potential inhibitors of the fungal cytochrome P-450 14α-demethylase. In testing for antifungal activity against a mouse systemic Candida albicans infection, (2R, 3R)-3-acylamino-2-aroyl-2-butanol derivatives III exhibited remarkably high efficacy after oral or parenteral administration. The structure-activity relationships of these amidoalcohols were evaluated.

• 社団法人日本薬学会の論文
• 1991-10-25

著者

• 安田 紘

  Biological Research Laboratories Sankyo Co. Ltd.

• 宮岡 武男

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 鴻巣 俊之

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,

• 田島 和

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,

• 老田 貞夫

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,

• 武田 憲子

  Medicinal Chemistry Research Laboratories Sankyo Co., Ltd.

• 笠原 真由美

  Biological Research Laboratories, Sankyo Co., Ltd.,

• 老田 貞男

  Medicinal Chemistry Research Laboratories Sankyo Co., Ltd.

• 武田 憲子

  Medical Chemistry Research Laboratories Sankyo Co. Ltd.

• 田島 和

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 鴻巣 俊之

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 笠原 真由美

  Biological Research Laboratories Sankyo Co. Ltd.

• 鴻巣 俊之

  Medicinal Chemistry Res. Laboratories Ii Daiichi Sankyo Co. Ltd.

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