Methylthiolated Cephem Derivatives

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概要

• 論文の詳細を見る

• Methylthiolation reactions of 7-benzamido-3-methyl-3-cephem-4-carboxylic ester (3) via its carbanion gave 4-substituted derivatives, whereas its oxide (7) gave 2-substituted derivatives exclusively. In the presence of excess base, 7-substituted compounds were also obtained. In addition, some alkylation reactions and zinc reductions of 2-methylthio compounds thereby obtained were investigated.

• 社団法人日本薬学会の論文
• 1975-11-25

著者

• 大木 英二

  Central Research Laboratories, Sankyo Co., Ltd.

• 老田 貞夫

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Chemical Research Laboratories Sankyo Co. Ltd.

• 大木 英二

  Research Laboratory Zenyaku Kogyo Co. Ltd.

• 大木 英二

  Central Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

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