Syntheses of Neamine Derivatives and Their Antibacterial Activities
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概要
- 論文の詳細を見る
1-N-[(S)-4-Amino-2-hydroxybutyryl]-neamine (3) derived from butirosin, an aminoglycoside antibiotic, has been chemically modified in its amide side chain. The N-benzenesulfonyl derivative (5) was hydrazinolysed and the resulting amine (6) was reacylated with another amino and/or hydroxy carboxylic acid. Removal of benzenesulfonyl groups were carried out with sodium in liquid ammonia, giving several kinds of analogues. In addition, an hydroxy epimer (31) and amino varients (25 and 30) in the α-position of the amide side chain of 3 were prepared starting from tetra-N-mono-O-benzenesulfonyl derivative (23). Antibacterial activity of these analogues were tested and discussed.
- 公益社団法人日本薬学会の論文
- 1974-05-25
著者
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大木 英二
Central Research Laboratories, Sankyo Co., Ltd.
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佐伯 博道
Central Research Laboratories, Sankyo Co., Ltd.
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島田 芳和
Central Research Laboratories, Sankyo Co., Ltd.
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大木 英二
Research Laboratory Zenyaku Kogyo Co. Ltd.
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大木 英二
Central Research Laboratories Sankyo Co. Ltd.
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菅原 眞一
Central Research Laboratories Sankyo Co. Ltd.
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島田 芳和
Central Research Laboratories Sankyo Co. Ltd.
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SUGAWARA SHINICHI
Central Research Laboratories, Sankyo Co., Ltd.
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OHKI EIJI
Central Research Laboratories, Sankyo Co., Ltd.
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佐伯 博道
Central Research Laboratories Sankyo Co. Ltd.
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