5,6-Epimino-D-glucofuranose and Synthesis of Nojirimycin (5-Amino-5-deoxyglucose)
スポンサーリンク
概要
- 論文の詳細を見る
Lithium aluminum hydride reduction of 6-azido-3-O-benzyl-6-deoxy-1,2-O-isopropylidene-β-L-idofuranose (5b) afforded 3-O-benzyl-5,6-dideoxy-5,6-epimino-1,2-O-isopropylidene-α-D-glucofuranose (1a). Its acetate (1b) was treated with acetic acid to give an 5-acetamido-6-O-acetyl-5-deoxy-derivative (6) which was transformed into a monosaccharide antibiotic, nojirimycin (2) which was produced by some strains of Streptomyces and showed activity against Sarcina lutea and Xanthomonas oryzae.
- 公益社団法人日本薬学会の論文
- 1968-12-25
著者
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佐伯 博道
Central Research Laboratories, Sankyo Co., Ltd.
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大木 英二
Central Research Laboratories Sankyo Co. Ltd.
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佐伯 博道
Central Research Laboratories Sankyo Co. Ltd.
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